<a href="#content" class="sr-only">Skip to content</a> <header id="masthead" x-data="{ open: false }"> <div class="relative w-full bg-white px-6 text-body"> <div class="mx-auto flex max-w-4xl items-end justify-between pt-5 pb-3"> <div class="flex items-end"> <p> <a href="/hcp/" rel="home"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho.png" width="229" height="37" alt="Homozygous Familial Hypercholesterolemia" class="h-auto w-[14.3125rem]" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho@2x.png 2x" /> </a> </p> <p class="ml-4 mb-[-0.03125rem] text-11px font-bold italic leading-12px text-magenta"> </p> </div> <nav id="site-navigation" aria-label="Main Navigation" class="hidden md:block"> <ul class="flex gap-x-2 text-13px leading-none [&_li]:after:float-right [&_li]:after:ml-2 [&_li]:after:block [&_li]:after:h-full [&_li]:after:w-px [&_li]:after:bg-grey-warm-15 [&_li]:after:content-[''] [&_li:last-child]:after:hidden"> </ul> </nav><!-- #site-navigation --> <span x-on:click="open = true" class="absolute right-0 top-0 flex aspect-square h-full items-center md:hidden"> <button type="button" class="mx-auto w-1/2"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 24 24" stroke-width="1.5" stroke="currentColor" class="h-full w-full"> <path stroke-linecap="round" stroke-linejoin="round" d="M3.75 6.75h16.5M3.75 12h16.5m-16.5 5.25h16.5" /> </svg> </button> </span> </div> </div> <div class="hidden w-full bg-magenta-15 px-6 md:block"> <nav id="home-navigation" class="mx-auto flex max-w-4xl items-end justify-between text-13px font-bold leading-4 tracking-[-0.25px] [&_a]:relative [&_a]:block [&_a]:py-3 [&_span]:inline-block [&_span]:border-r [&_span]:border-grey-warm [&_span]:px-3" aria-label="Home Navigation"> <ul class="-ml-3 flex text-body"> <li> <a href="/hcp/"><span >Sobre HFHo</span></a> </li> <li> <a href="/hcp/mecanismo/"><span >Mecanismo</span></a> </li> <li> <a href="/hcp/diagnostico/"><span >Diagnóstico</span></a> </li> <li> <a href="/hcp/impacto/"><span class="underline decoration-magenta decoration-8 underline-offset-[0.46875rem]" >Impacto</span></a> </li> <li> <a href="/hcp/acompanhamento/" class="[&_span]:border-none"><span >Acompanhamento</span></a> </li> </ul> </nav><!-- #home-navigation --> </div> <div x-dialog x-model="open" style="display: none" class="fixed top-0 left-0 z-50 h-full min-h-screen w-full overflow-y-auto md:hidden" > <div x-dialog:panel x-transition.opacity class="relative h-full w-full overflow-y-auto bg-grey-warm-15" > <div class="relative w-full bg-white px-6 text-body"> <div class="mx-auto flex max-w-4xl items-end justify-between pt-5 pb-3"> <p> <a href="https://www.hfho.com.br/" rel="home"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho.png" width="229" height="37" alt="Homozygous Familial Hypercholesterolemia" class="h-auto w-[14.3125rem]" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho@2x.png 2x" /> </a> </p> <span x-on:click="$dialog.close()" class="absolute right-0 top-0 flex aspect-square h-full items-center md:hidden"> <button type="button" class="mx-auto w-1/2"> <svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 24 24" stroke-width="1.5" stroke="currentColor" class="h-full w-full"> <path stroke-linecap="round" stroke-linejoin="round" d="M6 18L18 6M6 6l12 12" /> </svg> </button> </span> </div> </div> <nav class="border-t border-grey-warm-15 bg-white p-6 text-body"> <ul class="text-14px [&_li]:mt-3 [&_li:first-child]:mt-0"> </ul> </nav><!-- #site-navigation --> <div class="w-full bg-magenta-15 p-6"> <nav class="text-14px font-bold tracking-[-0.25px] [&_li]:mt-4"> <ul class="text-body [&_li:first-child]:mt-0"> <li> <a href="/hcp/"><span>Sobre HFHo</span></a> </li> <li> <a href="/hcp/mecanismo/"><span>Mecanismo</span></a> </li> <li> <a href="/hcp/diagnostico/"><span>Diagnóstico</span></a> </li> <li> <a href="/hcp/impacto/"><span>Impacto</span></a> </li> <li> <a href="/hcp/acompanhamento/"><span>Acompanhamento</span></a> </li> <!-- <li> <a href="/hcp/resources/"><span>Resources</span></a> </li> --> </ul> <!-- <ul class="text-magenta"> <li> <a href="/hcp/stay-up-to-date/"><span>Stay up-to-date</span></a> </li> </ul> --> </nav><!-- #home-navigation --> </div> </div> </div> </header><!-- #masthead --> <div id="content" class="bg-white text-body"> <section id="primary"> <main id="main" class="overflow-hidden"> <div class="hcp-header"> <div class="mx-auto flex max-w-4xl items-end justify-between md:items-start"> <h1 class="mb-16 max-w-custom self-center text-16px font-bold text-white xs:text-28px sm:text-36px md:mt-[3.625rem] md:ml-[2.75rem] md:self-auto"> Sem tratamento, a HFHo pode progredir rapidamente e levar a eventos cardiovasculares prematuros e mortalidade <sup>1–9</sup> </h1> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/people/header-impacto.png" width="264" height="312" class="w-[16.5rem] h-auto mt-[0.0625rem] md:mr-[2.375rem] -ml-[1.0625rem] max-w-[50%] sm:max-w-none" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/people/header-impacto.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/people/header-impacto@2x.png 2x" /> </div> </div> <div class="px-6"> <div class="mx-auto my-9 max-w-4xl text-16px sm:my-[4.5rem]"> <h2 class="text-28px font-bold">Progressão da doença</h2> <div class="mx-8 mt-11 text-12px md:mx-0 [&.flickity-loaded_.border-l-2]:h-full" id="timeline-carousel" @resize.window="$el.classList.remove('flickity-loaded')" @resize.window.debounce="$el.classList.add('flickity-loaded')" x-data="{}" > <div class="card1 extra-width w-full border-l-2 border-body-80 sm:w-1/2 md:w-1/4"> <h3 class="flag">No nascimento</h3> <div class="p-4"> <p> Os níveis de LDL-C são extremamente elevados, atingindo até ~696.06 mg/dL<sup>2</sup> </p> <p class="impact-red-para"> A doença se apresenta desde o nascimento<sup>2</sup> </p> </div> </div> <div class="card2 extra-width w-full border-l-2 border-body-80 sm:w-1/2 md:w-1/4"> <h3 class="flag">Durante a infÂNCIA</h3> <div class="p-4"> <p> Inicia-se o depósito de colesterol nos vasos sanguíneos e nas válvulas<sup>2</sup> </p> <p class="impact-red-para"> Em casos graves de HFHo, o primeiro infarto do miocárdio (IM) pode ocorrer antes dos 10 anos de idade<sup>1</sup> </p> </div> </div> <div class="card3 extra-width w-full border-l-2 border-body-80 sm:w-1/2 md:w-1/4"> <h3 class="flag md:w-48">dURANTE A ADOLESCÊNCIA</h3> <div class="p-4"> <p> O depósito de colesterol progride, causando estenose das artérias e comprometendo o funcionamento cardiovascular<sup>2</sup> </p> <p class="impact-red-para"> Mesmo em casos menos graves de HFHo, eventos cardiovasculares podem ocorrer<sup>2</sup> </p> </div> </div> <div class="card4 extra-width w-full border-l-2 border-body-80 sm:w-1/2 md:w-1/4"> <h3 class="flag">NA FASE ADULTA</h3> <div class="p-4 w-80"> <p> A estenose das artérias pode levar a episódios de IM, insuficiência cardíaca e/ou AVC<sup>2</sup> </p> <p class="impact-red-para"> A probabilidade de mortalidade na idade adulta aumenta, mesmo com o tratamento médico padrão<sup>2</sup> </p> </div> </div> </div> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/patient/timeline.svg" width="916" height="51" alt="" class="ml-[-1.125rem] h-auto w-[104.090909091%] max-w-none" /> <hr class="mt-11 border-grey-warm-40" /> <h2 class="mt-11 text-28px font-bold">O impacto da HFHo</h2> <p class="mt-3"> A HFHo representa um impacto considerável para os pacientes devido a sinais físicos e limitações causadas pela doença, bem como a uma série de fatores psicológicos.<sup>1,2</sup> </p> <div class="mt-6 md:flex md:gap-x-[4.5rem]"> <div class="md:w-[45.681818182%]"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-signs.png" width="74" height="88" class="h-auto w-[4.625rem]" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-signs.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-signs@2x.png 2x" /> <h3 class="mt-2 font-bold">Sinais visíveis, limitações físicas e sofrimento emocional devido aos efeitos da deposição de colesterol<sup>1,2</sup></h3> <ul class="yellow-bullets mt-6 [&_li:last-child]:mt-3"> <li>Sintomas como fadiga e falta de ar podem limitar a atividade física.</li> <li>Deposição cutânea de colesterol (xantomas) potencialmente desagradável, dolorosa ou até mesmo incapacitante.</li> </ul> </div> <div class="mt-8 md:mt-0 md:w-[41.818181818%]"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-functioning.png" width="74" height="88" class="h-auto w-[4.625rem]" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-functioning.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-functioning@2x.png 2x" /> <h3 class="mt-2 font-bold">Funcionamento psicossocial<sup>1</sup></h3> <p class="mt-2"> Os pacientes relataram sentir vergonha de sua condição, isolamento emocional e incerteza sobre a progressão da doença </p> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-family.png" width="74" height="88" class="h-auto w-[4.625rem] mt-8" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-family.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/impact-family@2x.png 2x" /> <h3 class="mt-2 font-bold">Impacto na atividade familiar e social<sup>1</sup></h3> <p class="mt-2"> Os pacientes relataram ser incapazes de participar de atividades sociais e esportivas. </p> </div> </div> <div class="mt-11 text-center"> <a href="/hcp/acompanhamento/" class="inline-block rounded-full bg-magenta px-4 pt-[0.4375rem] pb-1.5 text-16px font-bold uppercase text-white">SAIBA MAIS SOBRE O ACOMPANHAMENTO DA HFH<span class="normal-case">o</span></a> </div> <div class="mt-11 text-12px"> <h4 class="uppercase">REFERÊNCIAS</h4> <p class="mt-1.5"> 1. Cuchel M et al. <em>Eur Heart J</em>. 2014;35:2146–2157. 2. Bruckert E. <em>Atheroscler Suppl</em>. 2014;15:26–32. 3. de Gennes JL et al. <em>Arteriosclerosis</em>. 1985;5:440–442. 4. Patsch W et al. <em>J Clin Invest</em>. 1980;66:123–129. 5. Al-Shaikh AM et al. <em>Cardiol Young</em>. 2002;12:105–112. 6. Naoumova RP et al. <em>Curr Opin Lipidol</em>. 2004;15:413–422. 7. Raal FJ et al. <em>Atherosclerosis</em>. 2018;277:483–492. 8. Widhalm K et al. <em>J Pediatr</em>. 2011;158:167. 9. 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