<a href="#content" class="sr-only">Skip to content</a> <header id="masthead" x-data="{ open: false }"> <div class="relative w-full bg-white px-6 text-body"> <div class="mx-auto flex max-w-4xl items-end justify-between pt-5 pb-3"> <div class="flex items-end"> <p> <a href="/hcp/" rel="home"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho.png" width="229" height="37" alt="Homozygous Familial Hypercholesterolemia" class="h-auto w-[14.3125rem]" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/dark/hfho@2x.png 2x" /> </a> </p> <p class="ml-4 mb-[-0.03125rem] text-11px font-bold italic leading-12px text-magenta"> </p> </div> <nav id="site-navigation" aria-label="Main Navigation" class="hidden md:block"> <ul class="flex gap-x-2 text-13px leading-none [&_li]:after:float-right [&_li]:after:ml-2 [&_li]:after:block [&_li]:after:h-full [&_li]:after:w-px 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<li> <a href="/hcp/mecanismo/"><span>Mecanismo</span></a> </li> <li> <a href="/hcp/diagnostico/"><span>Diagnóstico</span></a> </li> <li> <a href="/hcp/impacto/"><span>Impacto</span></a> </li> <li> <a href="/hcp/acompanhamento/"><span>Acompanhamento</span></a> </li> <!-- <li> <a href="/hcp/resources/"><span>Resources</span></a> </li> --> </ul> <!-- <ul class="text-magenta"> <li> <a href="/hcp/stay-up-to-date/"><span>Stay up-to-date</span></a> </li> </ul> --> </nav><!-- #home-navigation --> </div> </div> </div> </header><!-- #masthead --> <div id="content" class="bg-white text-body"> <section id="primary"> <main id="main" class="overflow-hidden"> <div class="hcp-header"> <div class="mx-auto flex max-w-4xl items-end justify-between md:items-start"> <h1 class="mb-8 max-w-[24.25rem] self-center text-20px font-bold text-white xs:text-28px sm:text-36px md:mb-0 md:mt-[4.625rem] md:ml-[4.75rem] md:self-auto"> A redução do LDL-C é o principal objetivo do manejo da HFHo<sup>1</sup> </h1> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/people/header-acompanhamentoV1.png" width="238" height="313" class="w-[14.875rem] h-auto md:mr-[9.375rem] max-w-[50%] sm:max-w-none" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/people/header-acompanhamentoV1.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/people/header-acompanhamentoV1@2x.png 2x" /> </div> </div> <div class="px-6"> <div class="mx-auto my-9 max-w-4xl text-16px sm:my-[4.5rem]"> <div class="md:flex md:items-stretch md:gap-x-8"> <div class="mt-6 md:mt-0 md:h-full md:w-1 md:p-6"> <p class="font-bold"> O grau de redução do colesterol sérico alcançado por uma terapia é um importante determinante de sobrevida em pacientes com HFHo<sup>2</sup> </p> <p class="mt-2"> Em um estudo retrospectivo de 133 pacientes com HFHo, pacientes com colesterol sérico em tratamento >583,13 mg/dL tiveram 12 vezes mais risco de morte por causa cardíaca do que aqueles com colesterol sérico > 312,68 mg/dL.* </p> <ul class="ml-3 yellow-bullets"> <li class="mt-5 text-12px"> Levantamento retrospectivo dos níveis de lipídios e resultados clínicos de pacientes com HFHo tratados com uma combinação de medidas de redução de lipídios entre 1990 e 2014 na África do Sul e no Reino Unido. </li> </ul> </div> </div> <div class="mt-11 bg-grey-warm-15 p-6"> <h2 class="text-28px font-bold">Recomendações ESC/EAS 2023 para Redução do LDL-C</h2> <p class="mt-3"> Recomendações do Consenso EAS 2023 para nível alvo de LDL-C<sup>3</sup> </p> <div class="mt-6 sm:flex sm:gap-x-6"> <div class="mt-6 bg-white p-[1.125rem] text-center sm:mt-0 sm:w-1/3"> <h3 class="font-bold text-magenta">Crianças </h3> <p class="mt-2"> <115 mg/dL </p> </div> <div class="mt-6 bg-white p-[1.125rem] text-center sm:mt-0 sm:w-1/3"> <h3 class="font-bold text-magenta">Adultos (>18 anos)</h3> <p class="mt-2"> < 70 mg/dL </p> </div> <div class="mt-6 bg-white p-[1.125rem] text-center sm:mt-0 sm:w-1/3"> <h3 class="font-bold text-magenta">Adultos com ASCVD ou fatores de risco importantes para ASCVD</h3> <p class="mt-2"> < 54 mg/dL </p> </div> </div> </div> <p class="mt-8 text-10px"> ESC=European Society of Cardiology. EAS=European Atherosclerosis Society. </p> <div class="mt-11 sm:flex sm:gap-x-8"> <div class="sm:w-[30.795454545%]"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/management.png" width="273" height="213" class="sm:w-full h-auto" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/management.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/hcp/icons/management@2x.png 2x" /> </div> <div class="mt-6 sm:mt-0 sm:w-[65.568181818%]"> <h2 class="text-28px font-bold">A HFHo é tipicamente manejada com múltiplas abordagens de tratamento</h2> <p class="mt-3"> Intervenção no estilo de vida, incluindo<sup>3</sup> </p> <ul class="yellow-bullets mt-3"> <li>Dieta baixa em gordura saturada e colesterol</li> <li>Atividade física</li> <li>Manejo eficaz da hipertensão e diabetes</li> <li>Abstinência do fumo</li> </ul> <p class="mt-3"> Tratamentos farmacológicos, plasmaférese e, em circunstâncias raras para pacientes não responsivos, transplante hepático </p> </div> </div> <p class="mt-8 text-10px"> ASCVD=atherosclerotic cardiovascular disease. </p> <div class="mt-11 text-12px"> <h4 class="uppercase">REFERÊNCIAS</h4> <p class="mt-1.5"> 1. Brunham L et al. <em>Can J Cardiol</em>. 2018;35:1553-1563. 2. Thompson GR et al. <em>Eur Heart J</em>. 2018;39:1162–1168. 3. Cuchel M et al. <em>Eur Heart J</em>. 2023;44(25):2277-2291. </p> </div> </div> </div> </main><!-- #main --> </section><!-- #primary --> </div><!-- #content --> <footer id="colophon" class="w-full bg-body px-6"> <div class="mx-auto max-w-4xl py-4 text-white xs:py-10"> <nav id="footer-navigation" aria-label="Footer Navigation"> <ul class="text-12px leading-8 xs:flex xs:gap-x-10 xs:leading-none"> <li> <a href="https://www.ultragenyx.com/our-research/our-science/" target="_blank">Sobre a Ultragenyx</a> </li> <li> <a href="https://www.ultragenyx.com/brazilian-portuguese/privacy-policy/" target="_blank">Política de privacidade</a> </li> <li> <a href="https://www.ultragenyx.com/brazilian-portuguese/cookie-policy/" target="_blank">Politíca de cookies</a> </li> <li> <a href="https://www.ultragenyx.com/brazilian-portuguese/#fale_conosco" target="_blank">Fale conosco</a> </li> </ul> </nav><!-- #footer-navigation --> <hr class="my-8 border-body-80" /> <div class="xs:flex xs:items-end xs:justify-between"> <div class="xs:w-[56.81818182%] xs:pr-7"> <p> <a href="/hcp/" rel="home"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/light/hfho.png" width="229" height="37" alt="Homozygous Familial Hypercholesterolemia" class="h-auto w-[14.3125rem]" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/light/hfho.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/light/hfho@2x.png 2x" /> </a> </p> <p class="mt-3 text-10px md:text-9px"> As informações contidas nesta pagina são fornecidas pela Ultragenyx Brasil Farmacêutica Ltda. para fins educacionais para profissionais da saúde. </p> </div> <div class="mt-6 xs:mt-0 xs:w-[39.54545455%] xs:text-right"> <img src="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/ultragenyx.png" width="120" height="48" alt="Ultragenyx" class="inline h-12 w-auto" srcset="https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/ultragenyx.png, https://www.hfho.com.br/wp-content/themes/hofh/graphics/logos/ultragenyx@2x.png 2x" /> <p class="mt-2 text-10px"> Direitos Reservados © 2025 Ultragenyx Brasil Farmacêutica. <br> MRCC-UX858-00018 </p> </div> </div> </div> </footer><!-- #colophon --> </div><!-- #page --> <script type="speculationrules"> {"prefetch":[{"source":"document","where":{"and":[{"href_matches":"\/*"},{"not":{"href_matches":["\/wp-*.php","\/wp-admin\/*","\/wp-content\/uploads\/*","\/wp-content\/*","\/wp-content\/plugins\/*","\/wp-content\/themes\/hofh\/*","\/*\\?(.+)"]}},{"not":{"selector_matches":"a[rel~=\"nofollow\"]"}},{"not":{"selector_matches":".no-prefetch, .no-prefetch a"}}]},"eagerness":"conservative"}]} </script> <script src="https://www.hfho.com.br/wp-content/themes/hofh/js/script.min.js?ver=1.0.5" id="hofh-script-js"></script> </body> </html>